The Bills are one of the top contenders for the Super Bowl, while the Jaguars are coming off an awful season. Even if the Jags make the playoffs, they will likely still be the underdog.
What The Spread Tells Us
The spread usually indicates how much a team is favored to defeat another team. When the Bills faced the Jaguars last season, they were favored to win by 4.5 points and shattered the spread by miles after routing the Jags by 37 points.
What the Moneyline Tells Us
The moneyline usually details the team that is the consensus favorite. Sometimes, it's an overwhelming pick, and other times, it's a close call. The Bills were -240 moneyline favorites last season, which means you will get $41.67 plus the original $100 you wagered if you picked the Bills to win.
History of Bills vs. Jaguars
The Bills and Jaguars have not had many games over the years. However, there have been some solid games, including three playoff showdowns.
Bills' Record vs. Jaguars
The all-time, head-to-head series between the Bills and Jaguars is now 11-10 in favor of Buffalo (Jaguars lead 2-1 in playoffs). The teams have played 21 games, including three memorable playoff games.
All-Time Bills vs. Jaguars Games
Despite just 20 games, there has been plenty of exciting action, including two playoff games. Those playoff games are on this list of the best three games played between the Bills and Jaguars.
The first-ever game between the Jags and Bills was a playoff game! It started with Jim Kelly throwing a touchdown to Thurman Thomas. Then, the Jags answered back with a Pick-6 from Clyde Simmons, taking it back to the house to tie the game. Thomas ran it in to give the Bills a 14-7 lead. It was later 27-20 Bills in the fourth after a 38-yard interception touchdown return from Jeff Burns. But Jimmy Smith caught a touchdown pass from Mark Brunell to tie it. Finally, Mike Hollis won the game with a 45-yard field goal to send the Jags to the Divisional Round.
2. Buffalo Bills vs. Jacksonville Jaguars - January 11, 2026
The Bills and Jaguars delivered a Wildcard Weekend thriller on January 11, 2026, featuring six lead changes and nonstop momentum swings. Jacksonville appeared to seize control when Trevor Lawrence hit Travis Etienne Jr. for a touchdown with 3:58 remaining, giving the Jaguars a 24–20 lead. Josh Allen answered with a calm, methodical drive, capping it himself with a 1-yard rushing touchdown to put Buffalo ahead 27–24 with just 59 seconds left. Lawrence had one final opportunity, but his pass was tipped and intercepted by Cole Bishop, sealing the win for the Bills.
3. Jacksonville Jaguars vs. Buffalo Bills -September 12, 2004
Drew Bledsoe started things off with a touchdown pass to give the Bills a 7-0 lead. It was 10-6 Bills with time running out before Byron Leftwich passed to Ernest Wilford for a touchdown with time expiring to give the Jags a thrilling win.
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Injury Status for Buffalo Bills Vs Jacksonville Jaguars
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The Bills will likely play the Jaguars in the 2027 season, unless they meet in the playoffs again.
The Jaguars won the first-ever game against the Bills, which was an AFC Wildcard showdown on December 28, 1996. The Jags also won the first-ever regular-season game against the Bills 20-14 on December 14, 1997, with both games happening at Ralph Wilson Stadium.
The Bills and Jaguars have played 21 games in their history. The Bills lead the series 11-10, but the Jaguars are 2-1 in the playoffs.
The Bills and Jaguars do not play this season, but if they were to play, the Bills would likely be the favorites. The Bills were favorites last season and covered the spread by several touchdowns, showing how good this team really was.
If the Bills were to meet the Jaguars in the playoffs, you can place a bet on any of the officially licensed sportsbooks in Ontario. Some of these websites include DraftKings Sportsbook, Caesars Sportsbook, Bet365, FanDuel, BetMGM, and many more.
Brandon Justice has nearly a decade of experience covering sports and betting, primarily working in college football, college basketball, NFL and MLB. His goal is providing detailed analysis on the trends & data of sports betting with a wealth of experience, including writing for The Action Network & Rivals.com.
