Bills vs Cardinals Predictions & Odds: Who is Favored in Matchup?
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August 4, 2025 04:18pm
Bills vs. Cardinals Odds: Who Is Favored To Win?
The Bills and Cardinals are not scheduled to meet in the 2025 season. However, there is always a slight chance the teams could meet in the Super Bowl.
Key Takeaways
- The Bills defeated the Cardinals 34-28 in a thrilling Week 1 showdown on September 8, 2024.
- The Bills and Cardinals will likely next face off in 2028, with the game likely taking place in Glendale, Arizona.
Bills vs. Cardinals Odds: Who Is Favored To Win?
The Bills have the best odds to win the Super Bowl, while the Cardinals are in the middle ground. When the teams faced off last season in Orchard Park, the Bills were seven-point favorites, but the Cards covered the spread by losing by six points.
What The Spread Tells Us
The spread usually indicates how much better a team is than the other. In the case of the Cardinals vs. the Bills, oddsmakers gave the Bills seven points to cover the spread in 2024. But the Cards kept it close and lost by only six points.
What The MoneyLine Tells Us
The moneyline showcases the favorite in any particular game. The Bills were the overwhelming favorite to win this game against the Cards, and took care of business.
History of Bills vs. Cardinals
The Bills and Cardinals have not had many meetings throughout their history. So far, they have played a total of 13 games, including the battle in 2024. The Bills were favored to beat the Cardinals in Week 1, and won the game but did not cover the spread.
Bills' Record vs. Cardinals
The Bills are 8-5 in 13 games against the Cardinals. The series goes back to 1972, when the Cardinals were in St. Louis and continued when they moved to Phoenix, and then eventually to Glendale.
The last few games have been exciting. While Josh Allen has led the charge in Buffalo, Kyler Murray has been solid as the quarterback of the Cardinals.
All-Time Bills vs. Cardinals Games
There have been 13 games in the history of this series. Yet, it was pretty easy to whittle it down to the three best, with two of them happening in the last decade.
1. Cardinals vs. Bills -September 8, 2024
This game was a solid showdown from the start. The Cardinals led 17-3 at one point and seemed to be on the verge of pulling off the upset. Then, Josh Allen ran in for a touchdown before the half ended, and then threw two more in the third quarter. Ultimately, the defense held firmly, preventing the Cardinals from making any big plays toward the end.
2. Bills vs. Cardinals - November 15, 2020
The Bills were up 23-9 in the third quarter. But the Cardinals battled back, with 17 unanswered points to build a 26-23 lead. Buffalo retook the lead on a touchdown pass from Josh Allen to Stefon Diggs, and appeared to be on their way to victory. But a Hail Mary pass from Kyler Murray to DeAndre Hopkins with two seconds left sealed the deal for a stunning Cardinals' win.
3. Bills vs. Cardinals -October 14, 2012
This was a gritty game, and the Bills led 16-13 in the fourth quarter. But a field goal from Jay Feely tied it up, forcing overtime. Buffalo took care of business in the extra session, as Rian Lindell hit a game-winning field goal to seal it.
